Letter by Kataoka et al Regarding Article, “Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension: A View on the Right Ventricle”
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چکیده
منابع مشابه
Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension: A View on the Right Ventricle.
BACKGROUND The effect of a mutation in the bone morphogenetic protein receptor 2 (BMPR2) gene on right ventricular (RV) pressure overload in patients with pulmonary arterial hypertension is unknown. Therefore, we investigated RV function in patients who have pulmonary arterial hypertension with and without the BMPR2 mutation by combining in vivo measurements with molecular and histological anal...
متن کاملBone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a rapidly progressive and lethal disease, characterized by an increase in resistance of the pulmonary arterioles, causing an increased right ventricular (RV) afterload. The RV adapts to this increased load via several compensatory mechanisms, but these are not sufficient to prevent progression to RV dysfunction and failure, which is the predominant cause...
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متن کاملThe right ventricle in pulmonary arterial hypertension.
Pulmonary arterial hypertension (PAH) is a right heart failure syndrome. In early-stage PAH, the right ventricle tends to remain adapted to afterload with increased contractility and little or no increase in right heart chamber dimensions. However, less than optimal right ventricular (RV)-arterial coupling may already cause a decreased aerobic exercise capacity by limiting maximum cardiac outpu...
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ژورنال
عنوان ژورنال: Circulation
سال: 2016
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.116.022841